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J Toxicol Clin Toxicol. 1997;35(6):653-5.

Urinary mercury in twelve cases of cutaneous mercurous chloride (calomel) exposure: effect of sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy.

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1
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Auntónoma de Nuevo León, México.

Abstract

OBJECTIVE:

To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure.

SUBJECTS:

Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years.

DESIGN:

Twenty-four hour urine samples were collected for basal urine mercury. All the subjects received a 5-day cycle of oral sodium 2,3 dimercaptopropane-l-sulfonate (Dimaval capsules 100 mg) 200 mg/d on an outpatient basis. The urine mercury excretion was monitored 24 hours after the first dose and 72 hours after the last dose in eight subjects.

RESULT:

Exanthem and tremor were detected in two of 12 subjects. The range of urine mercury was 180 to 1876 micrograms/g creatinine. A significant increase in the urinary mercury excretion was observed in the first 24 hours after beginning sodium 2,3-dimercaptopropane-1-sulfonate.

CONCLUSION:

Chronic topical application of 5.9% HgCl cream was associated with clinical mercurialism in two subjects and with high urinary mercury level in all the cases. Sodium 2,3-dimercaptopropane-1-sulfonate was effective in increasing urine mercury.

PMID:
9365436
[Indexed for MEDLINE]
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