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Br J Cancer. 1997;76(9):1181-3.

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

Author information

1
Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam.

Abstract

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

PMID:
9365166
PMCID:
PMC2228133
DOI:
10.1038/bjc.1997.530
[Indexed for MEDLINE]
Free PMC Article

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