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Am J Vet Res. 1997 Nov;58(11):1193-6.

Use of carbamylated hemoglobin concentration to differentiate acute from chronic renal failure in dogs.

Author information

1
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.

Abstract

OBJECTIVE:

To determine usefulness of carbamylated hemoglobin (CarHb) concentration for differentiation of acute renal failure (ARF) from chronic renal failure (CRF) in dogs.

SAMPLE POPULATION:

Samples from dogs with ARF or CRF and from nonazotemic control dogs.

PROCEDURE:

CarHb concentration was determined in heparinized blood samples by measuring the micrograms of valine hydantoin (VH) per gram of hemoglobin (Hb), using a high-performance liquid chromatography assay, in which carbamyl valine is converted to VH via acid hydrolysis.

RESULTS:

CarHb concentration was significantly higher in dogs with ARF and CRF, compared with values in control dogs (ARF vs control, P < 0.05; CRF vs control, P < 0.001). Furthermore, CarHb concentration was significantly (P < 0.001) higher in dogs with CRF, compared with that in dogs with ARF. Carbamylated hemoglobin concentration did not correlate with serum urea nitrogen or creatinine concentration. Using a cutoff value of 100 micrograms of VH/g of Hb, the sensitivity and specificity of CarHb concentration for differentiating ARF from CRF was 96.1 and 84.2%, respectively.

CONCLUSIONS:

CarHb concentration was useful in the differentiation of ARF from CRF in the dogs of this study.

CLINICAL RELEVANCE:

CarHb concentration may be used to increase the accuracy of identifying ARF, so that early, aggressive management can be instituted, thereby increasing the chance of recovery.

PMID:
9361876
[Indexed for MEDLINE]

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