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Scand J Gastroenterol. 1997 Oct;32(10):974-9.

Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response.

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1
Dept. of Surgery, Kärnsjukhuset, Skövde, Sweden.

Abstract

BACKGROUND:

Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis.

METHODS:

Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks.

RESULTS:

At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively.

CONCLUSION:

Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis.

PMID:
9361168
DOI:
10.3109/00365529709011212
[Indexed for MEDLINE]
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