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Rheum Dis Clin North Am. 1997 Nov;23(4):797-809.

Methotrexate use in psoriasis and psoriatic arthritis.

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Department of Medicine, Louisiana State University School of Medicine at New Orleans, USA.


Methotrexate is an extremely effective drug in the treatment of psoriasis and psoriatic arthritis. In addition, it possesses a very high benefit-to-toxicity ratio compared with other therapies and immunosuppressive agents used in these disorders. Fortunately, most adverse events related to methotrexate are mild, but serious and life-threatening reactions, particularly liver toxicity, may occur. Careful monitoring is essential to prevent most undesirable side effects.

[Indexed for MEDLINE]

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