Two patients with salt-losing adrenal hyperplasia are reported. The occurrence of this condition among Blacks in Southern Africa has not yet been recorded. Both patients presented in the first month of life with dehydration, although they did not have diarrhoea. One was a boy, and the other a girl who had signs of virilisation. The typical biochemical changes of this condition were demonstrated. Congenital adrenal hyperplasia appears to be less common in Blacks than in Whites.