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Nat Biotechnol. 1997 Nov;15(12):1280-4.

A protein particle vaccine containing multiple malaria epitopes.

Author information

1
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.

Abstract

Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

PMID:
9359112
DOI:
10.1038/nbt1197-1280
[Indexed for MEDLINE]

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