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Immunol Today. 1997 Oct;18(10):478-82.

Th1-type immunity is incompatible with successful pregnancy.

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Dept. of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.


Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th1-type immunity may help resolve 'unexplained' pregnancy failure.

[Indexed for MEDLINE]

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