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Med Clin North Am. 1997 Nov;81(6):1347-57.

Cyclosporine-induced hypertension in cardiac transplantation.

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  • 1Department of Internal Medicine, Ochsner Medical Institutions, New Orleans, Louisiana, USA.


Cyclosporine-induced hypertension occurs in more than 90% of patients following cardiac transplantation. This article underlines the clinical characteristics as well as the mechanisms that can be associated with the development of cyclosporine-induced hypertension. In addition, the clinical trials up to date for the treatment of hypertension following cardiac transplantation are discussed. However, in view of the possible long-term sequelae associated with cyclosporine-induced hypertension, further studies to evaluate the long-term efficacy and safety of antihypertensive agents and finally the long-term effects of hypertension on the cardiac allograft are needed.

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