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Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12667-9.

Effects of muscarinic blockade in perirhinal cortex during visual recognition.

Author information

1
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892-4415, USA.

Abstract

Stimulus recognition in monkeys is severely impaired by destruction or dysfunction of the perirhinal cortex and also by systemic administration of the cholinergic-muscarinic receptor blocker, scopolamine. These two effects are shown here to be linked: Stimulus recognition was found to be significantly impaired after bilateral microinjection of scopolamine directly into the perirhinal cortex, but not after equivalent injections into the laterally adjacent visual area TE or into the dentate gyrus of the overlying hippocampal formation. The results suggest that the formation of stimulus memories depends critically on cholinergic-muscarinic activation of the perirhinal area, providing a new clue to how stimulus representations are stored.

PMID:
9356507
PMCID:
PMC25077
DOI:
10.1073/pnas.94.23.12667
[Indexed for MEDLINE]
Free PMC Article

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