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J Interferon Cytokine Res. 1997 Oct;17(10):583-7.

Infections in IFNGR-1-deficient children.

Author information

1
INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.

Abstract

Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccine or environmental nontuberculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.

PMID:
9355958
DOI:
10.1089/jir.1997.17.583
[Indexed for MEDLINE]

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