Abstract
This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2,3-bis(p-methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.
MeSH terms
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Animals
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Arachidonic Acid / toxicity
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Collagen / toxicity
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Drug Evaluation, Preclinical
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology*
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Pyrazines / chemistry
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Pyrazines / pharmacology*
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Rabbits
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Structure-Activity Relationship
Substances
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Platelet Aggregation Inhibitors
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Pyrazines
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Arachidonic Acid
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Collagen