Anti-platelet aggregation activity of some pyrazines

Biol Pharm Bull. 1997 Oct;20(10):1076-81. doi: 10.1248/bpb.20.1076.

Abstract

This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2,3-bis(p-methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Arachidonic Acid / toxicity
  • Collagen / toxicity
  • Drug Evaluation, Preclinical
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / pharmacology*
  • Pyrazines / chemistry
  • Pyrazines / pharmacology*
  • Rabbits
  • Structure-Activity Relationship

Substances

  • Platelet Aggregation Inhibitors
  • Pyrazines
  • Arachidonic Acid
  • Collagen