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Curr Opin Biotechnol. 1997 Oct;8(5):578-82.

Alphaviruses as expression vectors.

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F Hoffmann-La Roche, Research Laboratories, Roche Ltd, Basel, Switzerland.


Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology. Alphavirus vectors have also shown promising potential in vaccine production and preliminary gene therapy applications.

[Indexed for MEDLINE]

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