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Eur J Clin Microbiol Infect Dis. 1997 Sep;16(9):693-7.

Antifungal susceptibility testing of yeast isolates from blood cultures by microbroth dilution and the E test.

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Department of Microbiology, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.


The results of microbroth dilution were compared with those of the E test for 169 yeast isolates tested for their susceptibility to antifungal agents. All isolates were tested by both methods against amphotericin B, ketoconazole, fluconazole, and itraconazole. The E test results generally correlated well with those obtained by the reference method. There was at least 80% agreement of minimum inhibitory concentration results within two dilutions for all yeast species and agents tested, except for Cryptococcus neoformans tested with fluconazole (8% agreement). The E test appears to be a suitable alternative antifungal susceptibility test method for yeasts, although improvements are required for testing Cryptococcus neoformans against fluconazole.

[Indexed for MEDLINE]

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