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Trends Genet. 1997 Oct;13(10):410-4.

Sunlight and the onset of skin cancer.

Author information

1
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520-8040, USA. douglas.brash@yale.edu

Abstract

The photons of sunlight precipitate a series of genetic events in skin leading to cancer. These events involve somatic mutations as well as inherited alleles. Competition between cell populations ensues, as a single mutated cell expands into a clone. Thus cancer involves both a single-cell problem and a many-cell problem; in skin cancer, sunlight appears to drive both.

PMID:
9351343
DOI:
10.1016/s0168-9525(97)01246-8
[Indexed for MEDLINE]

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