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Trends Microbiol. 1997 Oct;5(10):409-13.

Pathogenesis of dengue virus diseases: missing pieces in the jigsaw.

Author information

1
Centre for Molecular Biotechnology (Arbovirology Group), School of Life Science, Queensland University of Technology, Brisbane, Australia. helle@biosci.ug.edu.au

Abstract

The mechanisms involved in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome remain unresolved. Antibody-dependent enhancement of infection has long been thought to play a central role; however, this remains unverified. The alternative hypothesis that virus variation, virulence and dynamics may account for severe dengue disease, particularly in children, should be considered.

PMID:
9351178
DOI:
10.1016/S0966-842X(97)01126-8
[Indexed for MEDLINE]

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