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Trends Microbiol. 1997 Oct;5(10):389-94.

Origins of the mobile gene cassettes found in integrons.

Author information

1
Dept of Biochemistry, University of Oxford, UK.

Abstract

Many of the acquired antibiotic resistance genes found in enterobacteria and pseudomonads are part of small mobile elements known as gene cassettes, and other genes are also likely to be found in cassettes. The origins of the genes and the recombination sites that make up cassettes are not known, but recent analyses of available data suggest that cassettes may be ancient structures, and some hypotheses for how they are formed can now be examined.

PMID:
9351174
DOI:
10.1016/S0966-842X(97)01123-2
[Indexed for MEDLINE]

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