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FEBS Lett. 1997 Sep 29;415(2):212-6.

Matrilin-3 from chicken cartilage.

Author information

1
MEM Institute, Division of Biology, University of Bern, Switzerland.

Abstract

By subtractive cDNA cloning we have identified a novel constituent of chicken cartilage termed matrilin-3. This constituent is encoded by a mRNA of 2.2 kbp whose expression is restricted to cartilaginous tissues. The predicted protein is composed of 452 amino acids with a molecular mass of 49 kDa. It contains a single von Willebrand factor A-like domain, four epidermal growth factor-like repeats and an alpha-helical region which may induce the formation of oligomers via a coiled-coil. The primary structure is similar to that of matrilin-1 which is also expressed in a cartilage-specific manner. This similarity suggests that the genes for the two proteins may have evolved from a common ancestor by gene duplication.

PMID:
9350998
DOI:
10.1016/s0014-5793(97)01126-5
[Indexed for MEDLINE]
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