A kallikrein-specific inhibitor in rat kidney tubules

Hoppe Seylers Z Physiol Chem. 1976 Apr;357(4):553-8. doi: 10.1515/bchm2.1976.357.1.553.

Abstract

A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikreins: porcine submanidbular and pancreatic kallikrein, rat kidney and urine kallikrein, and human urine and plasma kallikrein. An inhibition of bovine trypsin was not observed.

MeSH terms

  • Animals
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Kallikreins / antagonists & inhibitors*
  • Kidney Tubules / analysis*
  • Molecular Weight
  • Rats
  • Swine

Substances

  • Kallikreins