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J Neurol Sci. 1997 Oct 22;151(2):121-6.

Induction of the expression of gag protein in HTLV-I infected lymphocytes by anti-ICAM 1 antibody in vitro.

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Department of Neurology, Neurological Institute, Faculty of Medicine, Kyusyu University, Fukuoka, Japan.


Intercellular adhesion molecule 1 (ICAM 1) is an inducible protein ligand which is up-regulated during inflammation and is either not constitutively expressed or is only expressed at low levels. The expression of ICAM 1 increases in HTLV-I infected T cell lines as well as in CD4+ T-cells of peripheral blood lymphocytes (PBLs) from HAM/TSP patients. After PBLs of HAM/TSP patients were cultured in the presence of stimulating anti-ICAM 1 antibody, the expression of the HTLV-I gag protein in PBLs was observed by both immuno-histostaining and western blot analysis using HTLV-I Ag-specific mouse monoclonal antibody. These data thus suggested that the signal transduction via adhesion molecule, ICAM 1 could induce the transcription of the HTLV-I gene and this might therefore play an important role in the pathogenesis of HAM/TSP.

[Indexed for MEDLINE]

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