Format

Send to

Choose Destination
Cell. 1997 Oct 17;91(2):231-41.

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Author information

1
Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.

PMID:
9346240
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center