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Cell. 1997 Oct 17;91(2):197-208.

Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

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1
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA.

Abstract

Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation, definitive roles of PGs in various events of early pregnancy remain elusive. We demonstrate herein that the targeted disruption of COX-2, but not COX-1, in mice produces multiple failures in female reproductive processes that include ovulation, fertilization, implantation, and decidualization. Using multiple approaches, we conclude that these defects are the direct result of target organ-specific COX-2 deficiency but are not the result of deficiency of pituitary gonadotropins or ovarian steroid hormones, or reduced responsiveness of the target organs to their respective hormones.

PMID:
9346237
[Indexed for MEDLINE]
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