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Curr Opin Struct Biol. 1997 Oct;7(5):637-44.

Structural and sequence-based classification of glycoside hydrolases.

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Centre de Recherches sur les Macromolécules Végétales, CNRS, Joseph Fourier Université, Grenoble, France.


The diversity of oligo- and polysaccharides provides an abundance of biological roles for these carbohydrates. The enzymes hydrolysing these compounds, the glycoside hydrolases, therefore mediate a wealth of biological functions. Glycoside hydrolases fall into a number of sequence-based families. The recent analysis of these families, coupled with the burgeoning number of 3D structures, provides a detailed insight into the structure, function and catalytic mechanism of these enzymes.

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