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Biochem Biophys Res Commun. 1997 Oct 9;239(1):11-7.

The CD40 ligand directly activates T-lymphocytes via tyrosine phosphorylation dependent PKC activation.

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Department of Physiology, University of Tuebingen, Germany.


The activation of B-lymphocytes depends critically on the interaction of the CD40 receptor with its ligand. Here, we provide evidence that the CD40 ligand (CD40L) also functions as a direct stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via CD40L induces tyrosine phosphorylation of cellular proteins including PLC gamma. Tyrosine phosphorylation of PLC gamma correlates with an IP3- and Ca(2+)-release and an activation of PKC. Inhibition of src-like tyrosine kinases by Herbimycin A prevents these activation events suggesting a crucial role of tyrosine phosphorylation in T-lymphocyte activation via CD40L.

[Indexed for MEDLINE]

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