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Fungal Genet Biol. 1997 Aug;22(1):1-12.

The duplication cycle in Aspergillus nidulans.

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Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut, 06030-3205, USA.


The duplication cycle encompasses the spectrum of events required for the growth and division of individual cells within a fungal hyphae. Recent advances in understanding the mechanisms which underlie nuclear division and cellular morphogenesis in the filamentous fungus Aspergillus nidulans have shown that in many respects, the duplication cycle differs significantly from the cell cycles of both budding and fission yeast. The purpose of this review is to summarize these advances and to highlight the fundamental differences between the duplication cycle and the yeast cell cycles. In addition, it is argued that the duplication cycle is controlled by cellular regulatory networks which integrate the processes of nuclear division, cellular morphogenesis, and cell growth with each other. Functional dissection of these networks should help to reveal features that are unique to the hyphal mode of growth.

[Indexed for MEDLINE]

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