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Arch Otolaryngol Head Neck Surg. 1997 Oct;123(10):1057-60.

Chronic otitis media treated topically with ciprofloxacin or tobramycin.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Bnai Zion Medical Center; and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Abstract

OBJECTIVE:

To evaluate the efficacy of ciprofloxacin compared with tobramycin and placebo ear drops in the treatment of chronic suppurative otitis media without cholesteatoma.

DESIGN:

Sixty ears (in 51 patients) were randomly divided into 3 treatment groups: ciprofloxacin hydrochloride, tobramycin, and placebo interventions.

SETTING:

The otolaryngology department of a university teaching hospital.

INTERVENTION:

All ears were treated topically for 3 weeks.

MAIN OUTCOME MEASURES:

Each patient received a small, numbered bottle and was instructed to instill 5 drops 3 times daily for 3 weeks. The final clinical and bacteriologic assessment was made after 3 weeks.

RESULTS:

The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. Its sensitivity to ciprofloxacin and tobramycin was 94.2% and 70.6%, respectively. The clinical response was 78.9%, 72.2%, and 41.2% in the ciprofloxacin, tobramycin, and placebo groups, respectively. The bacteriologic response rate was 66.7% for the ciprofloxacin and tobramycin groups and 20% for the placebo group. Treatment with ciprofloxacin ear drops seemed to be as effective as treatment with tobramycin.

CONCLUSION:

While the lack of ototoxicity of ciprofloxacin was not tested in our study, this treatment may be considered as a potential topical therapy for cases of chronic suppurative otitis media.

PMID:
9339980
[Indexed for MEDLINE]

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