Format

Send to

Choose Destination
Arch Ophthalmol. 1997 Oct;115(10):1263-9.

Large cups in normal-sized optic discs: a variant of optic nerve hypoplasia in children with periventricular leukomalacia.

Author information

1
Department of Ophthalmology, Karolinska Institute, Huddinge University Hospital, Sweden.

Abstract

OBJECTIVE:

To evaluate optic disc morphologic features in children with periventricular leukomalacia (PVL).

PATIENTS AND METHODS:

Seventeen children with PVL (patient group) were compared with 17 sex- and age-matched, full-term healthy control children (control group). Clinical ophthalmological examination and digital image analysis of fundus photographs were performed in all children. In children with PVL, cerebral imaging was performed.

RESULTS:

Children with PVL had larger optic disc cupping (P<.02) than did control children. A large proportion of the children with PVL had strabismus, nystagmus, and restricted visual fields.

CONCLUSION:

Our study indicates that optic nerve hypoplasia in children with PVL is often associated with a normal-sized optic disc with a large cup. This unusual form of optic nerve hypoplasia most likely results from transsynaptic degeneration of optic axons caused by the primary bilateral lesion in the optic radiation.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center