Format

Send to

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 1997 Oct;100(4):563-8.

Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans.

Author information

1
Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, The University of Chicago, IL 60637, USA.

Abstract

BACKGROUND:

Sinusitis involves an inflammatory response with similarities to asthma.

OBJECTIVE:

We sought to determine whether a correlation exists between total IgE and the sinus mucosal thickening as assessed by computed tomography (CT) scans.

METHODS:

We screened the charts of 300 otolaryngology patients who had total and specific serum IgE determinations in 1994 and from this group selected all patients who had also undergone a sinus CT scan close to the time of serum evaluation (n = 86). Severity of disease on CT scan was graded by two investigators blinded to IgE levels.

RESULTS:

There was a significant positive correlation between severity of disease on CT scans and IgE (r[s] = 0.37, p = 0.0007). Furthermore, patients with a more advanced disease stage had higher IgE levels. There was also a positive correlation between severity of disease and the sum of specific IgE grades (r[s] = 0.29, p = 0.007).

CONCLUSION:

The data suggest that IgE levels or a linked genetic parameter may contribute to the mucosal inflammation in the paranasal sinuses.

PMID:
9338553
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center