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Nat Struct Biol. 1997 Oct;4(10):796-801.

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

Abstract

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

PMID:
9334743
[Indexed for MEDLINE]
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