Send to

Choose Destination
See comment in PubMed Commons below
Science. 1997 Oct 17;278(5337):452-5.

The homeotic gene lin-39 and the evolution of nematode epidermal cell fates.

Author information

Max-Planck Institut für Entwicklungsbiologie, Abteilung Zellbiologie, Spemannstrasse 35, 72076 Tübingen, Germany.


The fate of ventral epidermal cells differs among nematode species. Nonvulval cells fuse with the epidermis in Caenorhabditis elegans, whereas the homologous cells undergo apoptosis in Pristionchus pacificus. The homeotic gene lin-39 is involved in the regulation of these epidermal cell fates. In Caenorhabditis, lin-39 prevents cell fusion of potential vulval cells and specifies the vulva equivalence group. Pristionchus vulvaless mutants that displayed apoptosis of the vulval precursor cells were isolated, and point mutations in lin-39 were identified. Thus, the evolution of these epidermal cell fates is driven by different intrinsic properties of homologous cells.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center