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Neuroreport. 1997 Sep 29;8(14):3009-13.

Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats.

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1
Department of Psychology, University of New Orleans, LA 70148, USA.

Abstract

Ovariectomized adult Long-Evans rats received an eight-trial training session in a hippocampal-dependent hidden platform water maze task. Following trial 8, rats received an intra-hippocampal injection of estradiol in a water soluble cyclodextrin inclusion complex (1.0, 2.0 or 5.0 micrograms/0.5 microliter), or saline. Twenty-four hours later, the retention test escape latencies of rats administered post-training intra-hippocampal injections of estradiol (5.0 micrograms) were significantly lower than those of saline treated rats, indicating a memory-enhancing effect of estradiol. Injections of estradiol (5.0 micrograms) given 2 h post-training had no effect on retention, indicating a time-dependent effect of estradiol on memory storage processes.

PMID:
9331907
[Indexed for MEDLINE]
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