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Curr Opin Cell Biol. 1997 Oct;9(5):691-700.

Integrin signaling: specificity and control of cell survival and cell cycle progression.

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Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Cornell University, New York, NY 10021, USA.


Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.

[Indexed for MEDLINE]

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