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Curr Opin Cell Biol. 1997 Oct;9(5):683-90.

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

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1
Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, CA 94305-5426, USA. angelab@leland.stanford.edu

Abstract

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

PMID:
9330872
[Indexed for MEDLINE]
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