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Curr Opin Cell Biol. 1997 Oct;9(5):674-82.

Interendothelial junctions: structure, signalling and functional roles.

Author information

1
Vascular Biology Laboratory, Mario Negri Institute for Pharmacological Research, Milan, Italy.

Abstract

Endothelial cell-cell adhesive junctions are formed by transmembrane adhesive proteins linked to a complex cytoskeletal network. These structures are important not only for maintaining adhesion between endothelial cells and, as a consequence, for the control of vascular permeability, but also for intracellular signalling properties. The establishment of intercellular junctions might affect the endothelial functional phenotype by the downregulation or upregulation of endothelial-specific activities.

PMID:
9330871
DOI:
10.1016/s0955-0674(97)80121-4
[Indexed for MEDLINE]

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