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Crit Care Clin. 1997 Oct;13(4):829-48.

Poisoning by sodium channel blocking agents.

Author information

1
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona, USA.

Abstract

Poisoning by drugs that block voltage-gated sodium channels produces intraventricular conduction defects, myocardial depression, bradycardia, and ventricular arrhythmias. Human and animal reports suggest that hypertonic sodium bicarbonate may be effective therapy for numerous agents possessing sodium channel blocking properties, including cocaine, quinidine, procainamide, flecainide, mexiletine, bupivacaine, and others.

PMID:
9330843
DOI:
10.1016/s0749-0704(05)70371-7
[Indexed for MEDLINE]

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