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Semin Immunol. 1997 Oct;9(5):285-91.

IL-12 as an adjuvant for cell-mediated immunity.

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Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104, USA.


Recent studies have shown that IL-12 initiates the development of cell-mediated immunity following infection with certain infectious agents. This attribute of IL-12 makes it a potentially effective adjuvant for vaccines. This review summarizes our findings in the Leishmania system, outlining the role of endogenous IL-12 in resistance to L. major and the use of exogenous IL-12 in a vaccine against L. major, and also describes other examples in which IL-12 has been shown to be effective as an adjuvant at inducing protective immunity. The potential use of IL-12 as an adjuvant in therapeutic vaccines is also discussed.

[Indexed for MEDLINE]

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