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Am J Psychiatry. 1997 Oct;154(10):1454-5.

Luteinizing hormone pulse characteristics in depressed women.

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1
Department of Psychiatry, University of Minnesota Hospital, Minneapolis 55455-0392, USA.

Abstract

OBJECTIVE:

Luteinizing hormone (LH) pulse characteristics in depressed and normal women were compared to determine whether hypothalamic dysregulation in depression extends to the hypothalamic-pituitary-gonadal axis.

METHOD:

The subjects were 10 depressed and 13 normal comparison women admitted to a clinical research center. For each woman, an intravenous line was started and blood was withdrawn every 10 minutes for 8 hours. Blood samples were assayed for LH and LH pulse characteristics determined by using the computerized cluster algorithm of Veldhuis and Johnson.

RESULTS:

The depressed women differed significantly from the comparison women in LH pulse amplitude, rhythmicity, and area under the curve.

CONCLUSIONS:

Major depressive disorder is associated with abnormal regulation of luteinizing hormone. Gonadotropin regulation may provide a hormonal link between major depressive disorder and impaired fertility.

PMID:
9326832
DOI:
10.1176/ajp.154.10.1454
[Indexed for MEDLINE]
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