Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats

F U Afifi; E Khalil; S O Tamimi; A Disi

doi:10.1016/s0378-8741(97)00070-6

Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats

J Ethnopharmacol. 1997 Sep;58(1):9-14. doi: 10.1016/s0378-8741(97)00070-6.

Authors

F U Afifi¹, E Khalil, S O Tamimi, A Disi

Affiliation

¹ Faculty of Pharmacy, University of Jordan, Amman.

PMID: 9323999
DOI: 10.1016/s0378-8741(97)00070-6

Abstract

The possible antiulcerogenic activity of Laurus nobilis seeds was tested on experimentally (ethanol) induced gastric ulcer in rats. The results indicated antiulcerogenic activity for 20 and 40% aqueous extracts as well as for the oily fraction of these seeds. In acute toxicity studies, the aqueous extract was found safe with LD50 compared to oil LD50 0.33 ml/kg body weight.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Anti-Ulcer Agents / therapeutic use*
Disease Models, Animal
Ethanol / administration & dosage
Female
Lethal Dose 50
Male
Mice
Oils / chemistry
Plant Extracts / therapeutic use*
Plant Extracts / toxicity
Rats
Seeds
Stomach Ulcer / chemically induced
Stomach Ulcer / drug therapy*

Substances

Anti-Ulcer Agents
Oils
Plant Extracts
Ethanol