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Support Care Cancer. 1997 Sep;5(5):358-64.

Controversies in new antibiotic therapy for ambulatory patients.

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Ambulatory and Supportive Care Oncology Research Program (ASCORP), University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.


The care of the febrile neutropenic patient has undergone a shift in the last 10 years with the realization that neutropenic patients presenting with fever do not constitute a homogeneous group. Strategies of risk assessment have allowed the testing of novel therapies including outpatient treatment with oral and intravenous antibiotics, either in combination regimens or as monotherapy; the addition of growth factors to hasten the return of the absolute neutrophil count; and the possibility of self-initiation of antibiotics by cancer patients when they develop fever. The clinical trials data regarding these new approaches will be reviewed, and areas requiring further research will be discussed.

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