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Cell Tissue Res. 1997 Nov;290(2):299-306.

Patterning neuronal connections by chemorepulsion: the semaphorins.

Author information

1
Molekulare Neurogenetik, Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstrasse 46, D-60528 Frankfurt/Main, Germany.

Abstract

Axonal growth cones navigate long distances along specific pathways to establish complex patterns of neuronal connections. A growing number of signals have been identified that participate in these steering decisions. This review will concentrate on a large and growing family of chemorepellents, the semaphorins. This family contains both secreted and membrane-bound proteins expressed in many neuronal and non-neuronal tissues of invertebrates and vertebrates. Ongoing studies have given us a better understanding of how their highly conserved signalling system is involved in patterning neuronal connections.

PMID:
9321691
DOI:
10.1007/s004410050934
[Indexed for MEDLINE]

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