Format

Send to

Choose Destination
See comment in PubMed Commons below
Chest. 1997 Sep;112(3):759-64.

Extracorporeal membrane oxygenation for adult respiratory failure.

Author information

1
Heartlink ECMO Centre, Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, UK.

Abstract

OBJECTIVES:

To review the first 50 patients to receive extracorporeal membrane oxygenation (ECMO) for respiratory failure at Glenfield Hospital, and to compare them with published series of patients receiving positive pressure ventilation.

DESIGN:

Retrospective chart review.

SETTING:

Extracorporeal Life Support Organization/European Extracorporeal Life Support Organization recognized ECMO center.

PATIENTS:

Fifty consecutive patients referred for ECMO with respiratory failure refractory to conventional management between 1989 and 1995.

INTERVENTIONS:

None.

MEASUREMENTS AND RESULTS:

Primary end point was survival to hospital discharge, 66%. Other data (mean and SD): Murray Lung Injury Score, 3.4 (0.5); ratio of PaO2 to fraction of inspired oxygen, 65 (36.9) mm Hg; duration of ventilation pre-ECMO, 76.5 (83.7 h); peak airway pressure, 39.6 (7.4) cm H2O; end-expiratory pressure, 10 (3.3) cm H2O; minute ventilation, 12.6 (3.32) L/min; age, 30.1 (10.8) years; duration of ECMO, 207.4 (177.8) h; and units of blood transfused, 19 (17.3). Survival was significantly better than two previously reported series of patients receiving positive pressure ventilation (55.6% and 42% survival), p=0.036 and p=0.0006. Odds ratio for improved survival was 0.46 (95% confidence interval, 0.22 to 0.97, p=0.036).

CONCLUSIONS:

Survival with ECMO is 66% for adults with severe respiratory failure. ECMO should be considered in patients who remain hypoxic despite maximal positive pressure ventilation.

PMID:
9315812
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center