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Urol Int. 1997;59(1):23-5.

Vasectomy-induced superoxide dismutase inactivation in the male reproductive tract of rat: a prerequisite for spermatic granuloma formation.

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School of Life Sciences, DA University, Indore, India.


Post vasectomy spermatic granuloma formation is considered as a favourable development for vasectomized subjects as it maintains physiological hydrostatic pressure within the male reproductive tract. But, the 'state of the art' of the formation of granuloma after vasectomy is not well defined. The present study reveals a link between the postvasectomy free radical status of the male tract and spermatic granuloma formation after vasectomy. A surge in the rate of ascorbyl radical production, directly correlated with oxyradical stress and an abrupt fall in superoxide dismutase activity in the granuloma, indicates 'switching on' of a free radical-dependent machinery for the formation of granuloma after vasectomy.

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