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FEMS Microbiol Lett. 1997 Sep 15;154(2):385-8.

Mercury induces multiple antibiotic resistance in Escherichia coli through activation of SoxR, a redox-sensing regulatory protein.

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1
Departamento de Microbiología, LUSARA, México, D.F., Mexico.

Abstract

Sub-inhibitory mercury concentrations are capable of partially activating SoxR, as shown by the augmented expression of a soxS'::lacZ fusion, and a diminished sensitivity to antibiotics caused by mercury treatment. Mercury may elevate the intracellular concentration of superoxide or perhaps act as a putative metal ligand for SoxR.

PMID:
9311138
[Indexed for MEDLINE]
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