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FEMS Microbiol Lett. 1997 Sep 15;154(2):271-6.

In vitro plasmid-encoded resistance to quinolones.

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Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain.


The possibility of plasmid-encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild-type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy plasmid produced a quinolone resistance phenotype upon its expression in a quinolone-susceptible Escherichia coli strain.

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