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Structure. 1997 Aug 15;5(8):985-9.

Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology.

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Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661, USA.


Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.

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