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Curr Opin Genet Dev. 1997 Aug;7(4):551-7.

Notch in vertebrates.

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Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.


Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates. Connections have also been discovered between alterations in Notch function and human disease.

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