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Curr Opin Genet Dev. 1997 Aug;7(4):467-73.

From receptor to nucleus: the Smad pathway.

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Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.


The transforming growth factor-beta (TGF-beta) superfamily plays a central role in the specification and patterning of cells in the early embryo. Several years ago, the TGF-beta s were shown to signal through serine/threonine receptor kinases. Now, with the identification of Smad proteins, we can trace the TGF-beta signal transduction pathway from the receptors into the nucleus.

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