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Curr Opin Genet Dev. 1997 Aug;7(4):459-66.

Armadillo and dTCF: a marriage made in the nucleus.

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1
Department of Dermatology, University of North Carolina at Chapel Hill 27599-3280, USA.

Abstract

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.

PMID:
9309175
DOI:
10.1016/s0959-437x(97)80071-8
[Indexed for MEDLINE]

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