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FEBS Lett. 1997 Sep 1;414(1):153-8.

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).

Author information

1
Department of Biochemistry, University of Dundee, UK. slawler@bad.dundee.ac.uk

Abstract

A cDNA was cloned and expressed that encodes human stress-activated protein kinase kinase-4 (SKK4), a novel MAP kinase kinase family member whose mRNA is widely expressed in human tissues. SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38beta, SAPK3/ERK6 or SAPK4. It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila. In human epithelial KB cells SKK4 and SKK1/MKK4 (another activator of SAPK1/JNK) were both activated by stressful stimuli, but only SKK4 was activated by proinflammatory cytokines. The identification of SKK4 explains why the major SAPK1/JNK activator detected in many mammalian cell extracts is chromatographically separable from SKK1/MKK4.

PMID:
9305750
DOI:
10.1016/s0014-5793(97)00990-3
[Indexed for MEDLINE]
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