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Int J Biochem Cell Biol. 1997 Jun;29(6):861-5.

Thrombospondin-1.

Author information

1
MRC-Laboratory for Molecular Cell Biology, University College London, U.K.

Abstract

Thrombospondin-1 is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and that is also a transient component of extracellular matrix in developing and repairing tissues. It is a 420 kDa homotrimer, each subunit of which consists of multiple structural domains. A variety of factors regulate thrombospondin-1 expression and the protein is degraded by both extracellular and intracellular routes. Thrombospondin-1 functions as a cell adhesion molecule and also modulates cell movement, cell proliferation, neurite outgrowth and angiogenesis. The molecular mechanisms underlying these activities are beginning to be examined. Medical interest in thrombospondin-1 centres on its roles in haemostasis and its effects on angiogenesis.

PMID:
9304800
DOI:
10.1016/s1357-2725(96)00171-9
[Indexed for MEDLINE]

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